Prof.
Seunghyuk Choi
최승혁 교수
Computational Bioinformatics Lab.
Education
학력
Ph.D. Hanyang University, Computer Science (2022)
B.S. Hanyang University, Computer Science (2016)
B.S. Hanyang University, Computer Science (2016)
Career
경력
2026-Present Assistant Professor, Kookmin University
2023-2025 Postdoctoral Researcher, Baylor College of Medicine
2022-2023 Postdoctoral Researcher, Hanyang University
2023-2025 Postdoctoral Researcher, Baylor College of Medicine
2022-2023 Postdoctoral Researcher, Hanyang University
2026-현재 국민대학교 조교수
2023-2025 Baylor College of Medicine 박사후 연구원
2022-2023 한양대학교 박사후 연구원
2023-2025 Baylor College of Medicine 박사후 연구원
2022-2023 한양대학교 박사후 연구원
Research Overview 연구 개요
The lab focuses on decoding tumor biology and revealing new therapeutic targets by combining multi-omics approaches including mass spectrometry-based proteomics, next-generation sequencing, and advanced computational algorithms and AI models.
본 연구실은 질량분석 기반 프로테오믹스, 차세대 시퀀싱, 고급 컴퓨팅 알고리즘 및 AI 모델을 포함한 멀티오믹스 접근법을 결합하여 종양 생물학을 해독하고 새로운 치료 표적을 발굴하는 데 주력하고 있습니다.
Research Areas 연구 분야
- Computational Bioinformatics
- Proteomics
- Multi-omics
- AI for Drug Discovery
- 전산 생물정보학
- 프로테오믹스
- 멀티오믹스
- 신약 발굴을 위한 AI
Major Achievements 주요 연구 성과
- PepQueryMHC: Rapid tumor antigen prioritization from immunopeptidomics (Genome Biology 2025)
- Proteogenomic analysis reveals non-small cell lung cancer subtypes (Nature Communications 2024)
Recent Publications 주요 논문
- S. Choi and B. Zhang, "PepQueryMHC: Rapid and comprehensive tumor antigen prioritization from immunopeptidomics data," Genome Biology, 2025
- K. J. Song, M. Kim, Y. J. Heo, ..., S. Choi, ..., and M.-S. Kim, "Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability," Journal of Proteome Research, 2025
- S. Chang, R. Moon, D. Nam, ..., S. Choi, ..., and H. Park, "Hypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescence," Nucleic Acids Research, 2025
- J. Seo, S. Choi, and E. Paek, "NovoRank: Refinement for De Novo Peptide Sequencing Based on Spectral Clustering and Deep Learning," Journal of Proteome Research, 2025
- K. J. Song, S. Choi, ..., and M.-S. Kim, "Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment," Nature Communications, 2024
- S. Choi and E. Paek, "pXg: Comprehensive Identification of Noncanonical MHC-I-Associated Peptides From De Novo Peptide Sequencing Using RNA-Seq Reads," Molecular & Cellular Proteomics, 2024
- D. Y. Hyeon, D. Nam, ..., S. Choi, ..., "Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population," Nature Cancer, 2023
- S. Choi and E. Paek, "MutCombinator: identification of mutated peptides allowing combinatorial mutations using nucleotide-based graph search," Bioinformatics, 2020